Cancer wars: natural products strike back

Cancer wars: natural products strike back

Natural products have historically been a mainstay source of anticancer drugs, but in the 90's they fell out of favor in pharmaceutical companies with the emergence of targeted therapies, which rely on antibodies or small synthetic molecules identified by high throughput screening. Although targeted therapies greatly improved the treatment of a few cancers, the benefit has remained disappointin...

The microbes strike back.

Charming Penguins Strike Back

By using the recent experimental measurements of B → ππ and B → Kπ branching ratios, we find that factorization is unable to reproduce the observed BRs even taking into account the uncertainties of the input parameters. Charming and GIM penguins allow to reconcile the theoretical predictions with the data. Because of these large effects, we conclude, however, that it is not possible, with the p...

Premature Ventricular Contractions strike Back

Address for reprints: Dr. Carlos Labadet Av. Almirante Brown 240 CABA e-mail: [email protected] A BIT OF HISTORY Historically, premature ventricular contractions (PVCs) were considered precursors of sudden cardiac death and, for many years, their mere presence was taken as an indication for prescribing antiarrhythmic agents. The concept that ventricular fibrillation (VF) and ventricular tachyc...

Buckets Strike Back: Improved Parallel Shortest Paths

We study the average-case complexity of the parallel single-source shortest-path (SSSP) problem, assuming arbitrary directed graphs with n nodes, m edges, and independent random edge weights uniformly distributed in [0; 1℄. We provide a new bucket-based parallel SSSP algorithm that runs in T = O(log2 n minif2i L + jVijg) average-case time using O(n+m+T ) work on a PRAM where L denotes the maxim...